College football betting guide: Expert Week 7 CFB predictions, picks, odds & best bets

We have one heck of a college football slate coming our way this Saturday and it’s time to get excited. Not only will Texas and Oklahoma be renewing their Red River Rivalry, but powerhouses and National Championship contenders Ohio State and Oregon will be doing battle in Eugene as each...

April 17, 2026 • 7:46 AM

We have one heck of a college football slate coming our way this Saturday and it’s time to get excited. Not only will Texas and Oklahoma be renewing their Red River Rivalry, but powerhouses and National Championship contenders Ohio State and Oregon will be doing battle in Eugene as each school looks to earn a statement win. As well as those games, we a huge batch of great matchups to get excited for, and here at Pickswise, our team of expert CFB handicappers have you covered for ALL the big ones!

You can find all of our college football picks and CFB predictions for those matchups. On top of that, we have our top experts’ best bets of the day, along with our parlays and Same Game Parlay picks to help you bet better today across all of the NCAAF action. Let’s dive in!

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College football Week 7 best bets

Our top college football expert gives their best bets across Saturday’s huge slate.

CFB Week 7 best bets for Saturday — our experts went 4-1 on their best bets last week! See today’s top picks, featuring Penn State vs USC!

College football Week 7 parlays

See our CFB Week 7 parlay for Saturday’s games, while we have an SGPs for the huge Texas vs Oklahoma and Ohio State vs Oregon matchups.

College football Week 7 parlay — +651 odds!

Ohio State vs Oregon Same Game Parlay — +650 odds!

Texas vs Oklahoma Same Game Parlay — add even more excitement to this Red River clash with these 3 prop picks at +420 odds!

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College football Week 7 picks

Below, you’ll find our betting previews and NCAAF predictions for the hottest matchups in Week 7:

Ohio State vs Oregon prediction

Texas vs Oklahoma prediction

Georgia Tech vs North Carolina prediction

South Carolina vs Alabama prediction

Washington vs Iowa prediction

Wisconsin vs Rutgers prediction

Louisville vs Virginia prediction

Penn State vs USC prediction

Mississippi State vs Georgia prediction

Florida vs Tennessee prediction

Ole Miss vs LSU prediction

Kansas State vs Colorado prediction