College Football Week 10 opening lines, odds and best bet: Army ground game overpowers Air Force

We inch closer and closer to the College Football Playoff, as the calendar will soon flip to November. Like every week, I’ve got you covered with an opening line report, and will cap things off with a best bet. Unfortunately, Kansas State did not help the cause last week, so...

April 17, 2026 • 7:46 AM

We inch closer and closer to the College Football Playoff, as the calendar will soon flip to November. Like every week, I’ve got you covered with an opening line report, and will cap things off with a best bet. Unfortunately, Kansas State did not help the cause last week, so we are now 6-2 on these opening line best bets. However, I’ve already picked out my early best bet to get on right now to try and get us back into the win column this week. 

Below are the current lines and odds for college football Week 10’s biggest matchups, courtesy of Bet365 and available at the time of publishing on Sunday night. Don’t forget to check Pickswise throughout the week for all of our college football picks.

College football Week 10 opening lines and odds

Odds courtesy of Bet365 and available at time of publishing.

Texas State -3 (-115) vs Louisiana – Tuesday, October 29th 

Liberty -1 (-110) vs Jacksonville State – Wednesday, October 30th

Tulane -16 (-110) @ Charlotte – Thursday, October 31st

South Florida -2.5 (-110) @ Florida Atlantic – Friday, November 1st

Boise State -23.5 (-110) vs San Diego State – Friday, November 1st

Army -23.5 (-110) vs Air Force – Saturday, November 2nd

Miami -20.5 (-110) vs Duke – Saturday, November 2nd

Indiana -7 (-110) @ Michigan State – Saturday, November 2nd

Clemson -11 (-110) vs Louisville – Saturday, November 2nd

Minnesota -2.5 (-110) @ Illinois – Saturday, November 2nd

Ole Miss -6.5 (-110) @ Arkansas – Saturday, November 2nd

Northwestern -1.5 (-110) @ Purdue – Saturday, November 2nd

Ohio State -4 (-110) @ Penn State – Saturday, November 2nd

Auburn -6.5 (-115) vs Vanderbilt – Saturday, November 2nd

Virginia Tech -3.5 (-110) @ Syracuse – Saturday, November 2nd

UCF -6 (-110) vs Arizona – Saturday, November 2nd

Georgia -16.5 (-110) vs Florida – Saturday, November 2nd

Oregon -14.5 (-110) @ Michigan – Saturday, November 2nd

SMU -7 (-110) vs Pittsburgh – Saturday, November 2nd

Iowa State -14.5 (-110) vs Texas Tech – Saturday, November 2nd

Nebraska -7 (-115) vs UCLA – Saturday, November 2nd

Iowa -3.5 (-110) vs Wisconsin – Saturday, November 2nd

Tennessee -16 (-110) vs Kentucky – Saturday, November 2nd

Texas A&M -3.5 (-110) @ South Carolina – Saturday, November 2nd

Arizona State -1 (-110) @ Oklahoma State – Saturday, November 2nd

USC -2.5 (-110) @ Washington – Saturday, November 2nd

Baylor -3 (-110) vs TCU – Saturday, November 2nd

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NCAAF Week 10 opening line best bet: Army -23.5 over Air Force (-110)

This is a massive number for a game between service academies, especially coming off a mutual bye. However, I struggle to find a path to success for the Air Force defense in this game, as this unit is one of the least efficient in the country. The Falcons entered their bye week 125th in defensive PPA, and opposing rushing attacks have had their way with them. Air Force’s defense ranks 119th in rushing yards allowed per game (193.71), yielding more than 5 yards per attempt. Prior to their bye, the Falcons were outside the top 120 in opposing rush PPA and rush explosiveness, which are not good traits to have against this Army offense. The Black Knights have run the ball more than any other team in the country outside of garbage time since Week 4, and they are top 5 in rush PPA and rush success in that time. They also have a top-25 explosive rush rate, which should set their offense up for multiple scoring situations. 

Army averages 4.5 points per scoring opportunity outside of garbage time, and figures to meet little resistance in those situations against an Air Force defense that yields 5 points per opportunity and a touchdown on more than 70% of opposing red-zone trips. With an offense that averages the 4th-fewest points per game (15.3) and sits outside the top 90 in PPA since Week 4, I don’t trust Air Force to score enough to stay inside the number despite catching more than 3 touchdowns. For what it’s worth, Air Force already played Navy this season, and the Midshipmen won 34-7 with 329 rushing yards and 6.7 yards per carry. Army is more than capable of replicating that performance. Playable to -24.

Don’t miss our college football predictions for all of this week’s big matchups