MLS Week 2 Odds & Picks for March 5-6

MLS Week 2 kicks off this weekend with 14 matches Last week’s record: 3-2, +0.82 units Read on for the odds and our best bets for the weekend below One week is in the books as the 2022 MLS regular season kicked off last weekend. MLS Week 2 will kick...

April 17, 2026 • 5:17 AM

MLS Week 2 kicks off this weekend with 14 matches

Last week’s record: 3-2, +0.82 units

Read on for the odds and our best bets for the weekend below

One week is in the books as the 2022 MLS regular season kicked off last weekend. MLS Week 2 will kick off on Saturday with 12 matches, starting at 1:30 pm EST with New England hosting Dallas and concluding at 10:00 pm EST Sunday night with LAFC hosting Portland.

With Leg 1 of the CONCACAF Champions League Quarterfinals kicking off on Tuesday and Wednesday next week, the likes of NYCFC, Seattle, New England and Montreal may use some rotation this weekend.

Saturday will be a busy day of MLS action with 12 matches on Saturday, followed by just two on Sunday. Last week we went 3-2, betting a unit on each match, besides 0.30 units for the one draw bet. All picks below are for 1 unit.

MLS Week 2 Odds

Matchup Home Draw Away
New England vs FC Dallas -185 +320 +550
Toronto FC vs New York Red Bulls +160 +235 +180
Sporting KC vs Houston Dynamo -110 +260 +310
CF Montreal vs Philadelphia Union +145 +230 +200
San Jose Earthquakes vs Columbus Crew +170 +240 +165
Chicago Fire vs Orlando City SC -120 +275 +350
Colorado Rapids vs Atlanta United +110 +265 +240
FC Cincinnati vs DC United +240 +270 +110
Minnesota United vs Nashville SC +145 +225 +210
Real Salt Lake vs Seattle Sounders +185 +225 +160
Vancouver Whitecaps vs New York City FC +265 +265 +105
Charlotte FC vs LA Galaxy +230 +255 +120
Austin FC vs Inter Miami CF -160 +300 +475
Los Angeles FC vs Portland Timbers -160 +330 +425

Odds from March 4 at DraftKings

The Revolution are the biggest favorite on the board this weekend, hosting FC Dallas. Then, it’s second-year side Austin FC as -160 favorites at home to Inter Miami. The biggest game of the weekend is also the last when LAFC hosts Portland Sunday night also as -160 favorites themselves.

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