MLS Week 5 Odds & Picks: Toronto FC vs NYCFC, Portland vs LA Galaxy & More

MLS Week 5 offers up a huge slate of Saturday action Last week’s record: 2-1, +0.48 units; Season Record 10-5, +3.47 units Read on for the odds and our best bets for the MLS Week 5 below After a busy international break, Major League Soccer resumes with MLS Week 5...

April 17, 2026 • 5:16 AM

MLS Week 5 offers up a huge slate of Saturday action

Last week’s record: 2-1, +0.48 units; Season Record 10-5, +3.47 units

Read on for the odds and our best bets for the MLS Week 5 below

After a busy international break, Major League Soccer resumes with MLS Week 5 this weekend. It will be a jam-packed Saturday of action as 13 games take place, all starting at 3:30 pm or later. Sunday features a standalone match where Portland hosts the Galaxy at 4:30 pm EST.

Read on for the odds for MLS Week 5 below, followed by our two top plays for the weekend, as well as a two-team parlay bet.

MLS Week 5 Odds

Matchup Home Draw Away
Chicago Fire vs FC Dallas +102 +245 +275
FC Cincinnati vs CF Montreal +145 +250 +180
Toronto FC vs NYCFC +230 +250 +116
Columbus Crew vs Nashville SC -102 +225 +320
DC United vs Atlanta United +122 +245 +220
New England Revolution vs New York Red Bulls +106 +255 +255
Orlando City SC vs LAFC +170 +240 +160
Philadelphia Union vs Charlotte FC -225 +350 +625
San Jose Earthquakes vs Austin FC +150 +250 +175
Inter Miami vs Houston Dynamo +140 +235 +200
Minnesota United vs Seattle Sounders +114 +240 +245
Vancouver Whitecaps vs Sporting KC +165 +225 +175
Colorado Rapids vs Real Salt Lake -135 +270 +380
Portland Timbers vs LA Galaxy +118 +255 +220

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When deciding on the pros and cons of betting on these teams, remember that most have been off for the past two weeks. Only three games took place last weekend. These include Charlotte vs Cincinnati, SKC vs RSL, and Portland vs Orlando.

With legal Canadian sports betting launching on Monday, April 4, Toronto FC bettors will soon be able to bet on the Reds through a variety of legal sportsbooks such as theScore Bet.

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