Guardians vs White Sox Odds & Picks (July 23)

The Chicago White Sox are -115 home favorites over the Cleveland Guardians in an American League afternoon game on the docket for Saturday, July 23 It’s the opener of a day-night doubleheader between these AL Central rivals The White Sox have won two of the last three meetings with the...

April 17, 2026 • 1:06 AM

The Chicago White Sox are -115 home favorites over the Cleveland Guardians in an American League afternoon game on the docket for Saturday, July 23

It’s the opener of a day-night doubleheader between these AL Central rivals

The White Sox have won two of the last three meetings with the Guardians but Cleveland holds a 7-3 straight up edge in the season series

The Cleveland Guardians (47-44, 22-25 away) and Chicago White Sox (46-47, 19-26 home) are both within striking distance of the Minnesota Twins for the American League Central Division lead. That’s making this weekend four-game series between the two clubs all the more significant.

Cleveland launched the first salvo via an 8-2 victory on Friday. The two clubs will play a day-night doubleheader on Saturday.

First pitch at Guaranteed Rate Field is set for 1:10pm ET on Saturday, July 23. Thunderstorms with 11 mph wind and a temperature of 92 degrees are in the weather forecast.

Guardians vs White Sox Odds

Team Moneyline Runline Total
Cleveland Guardians -105 +1.5 (-210) O 8.5 (-120)
Chicago White Sox -115 -1.5 (+175) U 8.5 (+100)

Odds as of July 22 at Caesars Sportsbook. See available Caesars Sportsbook promo codes. 

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