Cardinals vs Cubs Odds, Picks & Predictions (Aug 25)

The Cardinals vs Cubs odds favor St. Louis as -130 moneyline favorites on Thursday, August 25, at 2:20pm ET St. Louis will give the ball to Dakota Hudson (6-6, 4.33 ERA), while Chicago will counter with Marcus Stroman (3-5, 3.83 ERA) Read below for the Cardinals vs Cubs odds and...

April 16, 2026 • 10:32 AM

The Cardinals vs Cubs odds favor St. Louis as -130 moneyline favorites on Thursday, August 25, at 2:20pm ET

St. Louis will give the ball to Dakota Hudson (6-6, 4.33 ERA), while Chicago will counter with Marcus Stroman (3-5, 3.83 ERA)

Read below for the Cardinals vs Cubs odds and betting prediction

Any doubt about the potency of the St. Louis Cardinals (71-52, 31-31 away) lineup was put to rest on Tuesday evening in Chicago. After scoring just one run through the first two games of their series with the Cubs (53-70, 27-37 home), St. Louis pounded 16 hits and crossed the plate 13 times in a 13-3 drubbing of their NL Central rival.

Oddsmakers are expecting another Cardinals victory on Thursday in the series finale, although perhaps not of the lopsided variety.

Cardinals vs Cubs Odds

Team Moneyline Runline Total
St. Louis Cardinals -130 -1.5 (+120) Ov 9 (-115)
Chicago Cubs +110 +1.5 (-140) Un 9 (-105)

Odds as of August 22 at Caesars Sportsbook. See available Caesars Sportsbook bonus code.

 

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