Tigers vs Pirates Odds, Predictions & Player Prop Picks (July 21)

Pirates phenom Paul Skenes faces Tigers veteran Jack Flaherty on Monday night in Pittsburgh Despite a significant disparity in win/loss records, the Pirates are slight home favorites, a testament to the market’s respect for Skenes Below, see the Tigers vs Pirates odds, plus my predictions and player-prop picks for DET...

April 16, 2026 • 10:07 AM

Pirates phenom Paul Skenes faces Tigers veteran Jack Flaherty on Monday night in Pittsburgh

Despite a significant disparity in win/loss records, the Pirates are slight home favorites, a testament to the market’s respect for Skenes

Below, see the Tigers vs Pirates odds, plus my predictions and player-prop picks for DET vs PIT tonight

The Detroit Tigers (60-40, 28-22 away, 50-45-5 O/U) travel to the Steel City to take on the Pittsburgh Pirates (39-61, 26-24 home, 39-57-4 O/U) on Monday, July 21st. First pitch is scheduled for 6:40 pm ET from PNC Park in Pittsburgh, with sensational sophomore Paul Skenes set to take the mound for the home team against veteran Jack Flaherty for the visitors.

Though the Pirates are on a dismal slide and sit second-last in the NL, they are slight home favorites against the AL-leading Tigers with their ace on the mound.

Jump to: DET vs PIT Odds | Batter-vs-Pitcher Stats | DET vs PIT Player Props | DET vs PIT Prediction

Detroit Tigers vs Pittsburgh Pirates Odds

et TypeTigersPirates
Run Line +1.5 (-214) -1.5 (+176)
Moneyline +105 -125
Total Runs O 7.0 (-118) U 7.0 (-102)

The Tigers/Pirates odds set Pittsburgh as a -125 favorite on the moneyline, with Detroit listed at +105. Taking out the juice, the moneyline gives Pittsburgh a 53.2% implied win probability and Detroit 46.8%. On the runline, the Tigers are a short -214 to keep the score within a run, while the Pirates are +176 to win by multiple runs. The total is set at a low 7.0 runs, acknowledging the potential for a pitchers’ duel between Skenes and Flaherty, who has the luxury of facing a struggling Pittsburgh lineup.

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