Missouri vs Texas A&M Odds, Lines & Predictions – CFB Week 6

#9 Missouri travels to College Station to face #25 Texas A&M on Saturday, October 5 Texas A&M leads the all-time series over Mizzou 9-7 Keep reading for the latest Missouri vs Texas A&M odds and predictions for CFB Week 6 The sole Top 25 SEC matchup in Week 6 of...

April 16, 2026 • 7:21 AM

#9 Missouri travels to College Station to face #25 Texas A&M on Saturday, October 5

Texas A&M leads the all-time series over Mizzou 9-7

Keep reading for the latest Missouri vs Texas A&M odds and predictions for CFB Week 6

The sole Top 25 SEC matchup in Week 6 of the college football season kicks off at noon ET at Kyle Field. Missouri enters this game with a 4-0 record after narrowly beating Vanderbilt at home in overtime. Texas A&M is 4-1. The Aggies have won four in a row, including two SEC wins, after losing their opener to Notre Dame in Week 1.

Texas A&M is 9-7 all-time vs Missouri and won their last meeting in 2021. Missouri has won seven of the last ten in this series, however.

This is a big game for both teams looking to make it into the field of the extended College Football Playoff bracket. See below for the latest odds for Missouri vs Texas A&M on Saturday and my predictions for this SEC bout.

Missouri vs Texas A&M Odds

Team Spread Moneyline Total
Missouri Tigers +2.5 (-110) +110 Over 48.5 (-105)
Texas A&M Aggies -2.5 (-110) -130 Under 48.5 (-115)

Despite being ranked in the Top Ten, Missouri is listed as an underdog to Texas A&M in the latest college football odds. The Aggies are -2.5 vs the Tigers and with -130 odds on the moneyline, they have an implied win probability of 56.52%. After CFB Week 5, Texas A&M was -1.5 before moving to -2.5.

The total in this SEC matchup is 48.5. It opened at O/U 49.5 but has since moved down a point.

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