Opening Odds for All CFP First-Round Games

The 12-team CFP playoff field has been set The Alabama vs Oklahoma odds are almost a pick’em See the opening odds for all first-round College Football Playoff games The 12-team College Football Playoff bracket has been set. The first round will feature #12 James Madison vs #5 Oregon, #11 Tulane...

April 16, 2026 • 6:56 AM

The 12-team CFP playoff field has been set

The Alabama vs Oklahoma odds are almost a pick’em

See the opening odds for all first-round College Football Playoff games

The 12-team College Football Playoff bracket has been set. The first round will feature #12 James Madison vs #5 Oregon, #11 Tulane vs #6 Ole Miss, #10 Miami vs #7 Texas A&M, and #9 Alabama vs #8 Oklahoma, with the better-seeded team hosting each game.

The table below lists the opening odds for all four first-round CFP games.

Opening CFP Odds

TeamSpreadMoneylineTotal
#12 James Madison +21.5 (-110) +1100 O 51.5 (-110)
#5 Oregon -21.5 (-110) -2100 U 51.5 (-110)
TeamSpreadMoneylineTotal
#11 Tulane +16.5 (-110) +625 O 55.5 (-110)
#6 Ole Miss -16.5 (-110) -950 U 55.5 (-110)
TeamSpreadMoneylineTotal
#9 Alabama +1.5 (-110) -105 O 42.5 (-110)
#8 Oklahoma -1.5 (-110) -115 U 42.5 (-110)
TeamSpreadMoneylineTotal
#10 Miami +5.5 (-110) +160 O 52.5 (-110)
#7 Texas A&M -5.5 (-110) -192 U 52.5 (-110)

The top-four seeds waiting in the quarterfinals are: #1 Indiana, #2 Ohio State, #3 Georgia, and #4 Texas Tech. Though the Hoosiers took down the Buckeyes (13-10) in a low-scoring Big Ten title game, Ohio State remains the favorite in the national championship odds (+240), closely followed by undefeated Indiana (+250).

These are the early CFP Round 1 odds, but we are also tracking the full opening college football bowl game odds and lines for 2025-26.

Odds as of 12:55 pm ET at DraftKings. Claim the DraftKings Missouri promos before betting on the College Football Playoff.

Biggest CFP Spread

The biggest spread on the board by a wide margin is #5 Oregon laying over three touchdowns against James Madison, a team that only squeaked in because 8-5 Duke managed to steal the ACC championship.

The Dukes only played on a power-conference team this season, losing 28-14 at Louisville. They ran the table in the Sun Belt, winning each game by at least a touchdown. They also beat Washington State 24-20.

Highest CFP Total

The highest total on the board is 55.5 in #11 Tulane vs #6 Ole Miss. The Rebels went 6-6 O/U this season, with their games averaging 57.4 PPG. Tulane was just 4-9 O/U, with their games averaging just 51.7 PPG.

Early CFP Odds Movement

The most notable odds movement early on is Miami going from a +5.5-point road underdog at Texas A&M to just +4.0. The 10-2 Canes have won four in a row, while the 11-1 Aggies are coming off their only loss of the season – 27-17 at Texas – a setback that kept them out of the SEC title game and ultimately doomed them to a first-round game.

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