The 68-team NCAA Tournament field is set and first-round matchups are on the board
One double-digit seed is favored in its first-round matchup
See the odds for all available 2025 March Madness first-round games, below
The odds are out for all the first-round and first four matchups at the 2025 NCAA Tournament. The table below lists the opening spread, moneyline and game total for all 32 games currently on the board. Under the table find notes on the biggest spreads and highest/lowest totals for the round of 64.
March Madness First-Round Odds for All Games
| Team | Spread | ML | Total |
|---|---|---|---|
| #11 Xavier | -2.5 (-110) | -148 | O 149.5 (-110) |
| #11 Texas | +2.5 (-110) | +124 | U 149.5 (-110) |
| Team | Spread | ML | Total |
| #16 Saint Francis | +3.5 (-110) | +142 | O 140.5 (-110) |
| #16 Alabama St | -3.5 (-110) | -170 | U 140.5 (-110) |
| Team | Spread | ML | Total |
| #11 North Carolina | -4.5 (-105) | -184 | O 142.5 (-110) |
| #11 San Diego State | +4.5 (-115) | +154 | U 142.5 (-110) |
| Team | Spread | ML | Total |
| #13 High Point | +8.5 (-118) | +295 | O 153.5 (-110) |
| #4 Purdue | -8.5 (-102) | -375 | U 153.5 (-110) |
| Team | Spread | ML | Total |
| #16 Mt St Mary’s | +1.5 (-110) | +105 | O 133.5 (-110) |
| #16 American | -1.5 (-110) | -125 | U 133.5 (-110) |
| Team | Spread | ML | Total |
| #11 Drake | +6.5 (-112) | +210 | O 133.5 (-110) |
| #6 Missouri | -6.5 (-108) | -258 | U 133.5 (-110) |
| Team | Spread | ML | Total |
| #14 UNCW | +15.5 (-105) | +1100 | O 143.5 (-110) |
| #3 Texas Tech | -15.5 (-115) | -2100 | U 143.5 (-110) |
| Team | Spread | ML | Total |
| #10 Arkansas | +4.5 (-110) | +164 | O 145.5 (-110) |
| #7 Kansas | -4.5 (-110) | -198 | U 145.5 (-110) |
| Team | Spread | ML | Total |
| #15 Omaha | +17.5 (-110) | +950 | O 145.5 (-110) |
| #2 St John’s | -17.5 (-110) | -1650 | U 145.5 (-110) |
| Team | Spread | ML | Total |
| #9 Georgia | +6.5 (-115) | +215 | O 151.5 (-110) |
| #8 Gonzaga | -6.5 (-105) | -265 | U 151.5 (-110) |
| Team | Spread | ML | Total |
| #13 UC San Diego | +3.5 (-110) | +140 | O 140.5 (-110) |
| #5 Michgan | -3.5 (-110) | -166 | U 140.5 (-110) |
| Team | Spread | ML | Total |
| #13 Yale | +7.5 (-115) | +250 | O 140.5 (-115) |
| #4 Texas A&M | -7.5 (-105) | -310 | U 140.5 (-105) |
| Team | Spread | ML | Total |
| #11 VCU | +3.5 (-112) | +142 | O 144.5 (-110) |
| #6 BYU | -3.5 (-108) | -170 | U 144.5 (-110) |
| Team | Spread | ML | Total |
| #14 Montana | +16.5 (-105) | +1200 | O 149.5 (-110) |
| #3 Wisconsin | -16.5 (-115) | -2400 | U 149.5 (-110) |
| Team | Spread | ML | Total |
| #15 Bryant | +17.5 (-108) | +1200 | O 150.5 (-115) |
| #2 Michigan State | -17.5 (-112) | -2400 | U 150.5 (-105) |
| Team | Spread | ML | Total |
| #16 SIUE | +28.5 (-108) | +2500 | O 126.5 (-110) |
| #1 Houston | -28.5 (-112) | -9000 | U 126.5 (-110) |
| Team | Spread | ML | Total |
| #14 Troy | +10.5 (-102) | +500 | O 152.5 (-112) |
| #3 Kentucky | -10.5 (-118) | -700 | U 152.5 (-108) |
| Team | Spread | ML | Total |
| #16 Norfolk State | +28.5 (-110) | +5000 | O 153.5 (-115) |
| #1 Florida | -28.5 (-110) | -100000 | U 153.5 (-105) |
| Team | Spread | ML | Total |
| #9 Oklahoma | +4.5 (-108) | +164 | O 146.5 (-110) |
| #8 UConn | -4.5 (-112) | -198 | U 146.5 (-110) |
| Team | Spread | ML | Total |
| #12 Colorado State | -2.5 (-108) | -142 | O 147.5 (-110) |
| #5 Memphis | +2.5 (-112) | +120 | U 147.5 (-110) |
| Team | Spread | ML | Total |
| #9 Baylor | +2.5 (-115) | +114 | O 143.5 (-110) |
| #8 Miss. State | -2.5 (-105) | -135 | U 143.5 (-110) |
| Team | Spread | ML | Total |
| #14 Lipscomb | +13.5 (-102) | +800 | O 143.5 (-110) |
| #3 Iowa State | -13.5 (-118) | -1350 | U 143.5 (-110) |
| Team | Spread | ML | Total |
| #10 New Mexico | +3.5 (-105) | +145 | O 151.5 (-108) |
| #7 Marquette | -3.5 (-115) | -175 | U 151.5 (-112) |
| Team | Spread | ML | Total |
| #12 Liberty | +6.5 (-110) | +245 | O 139.5 (-112) |
| #5 Oregon | -6.5 (-110) | -305 | U 139.5 (-108) |
| Team | Spread | ML | Total |
| #13 Akron | +14.5 (-115) | +750 | O 167.5 (-105) |
| #4 Arizona | -14.5 (-105) | -1200 | U 167.5 (-115) |
| Team | Spread | ML | Total |
| #10 Vanderbilt | +3.5 (-105) | +150 | O 136.5 (-110) |
| #7 Saint Mary’s | -3.5 (-115) | -180 | U 136.5 (-110) |
| Team | Spread | ML | Total |
| #15 Robert Morris | +22.5 (-110) | +2000 | O 165.5 (-110) |
| #2 Alabama | -22.5 (-110) | -6500 | U 165.5 (-110) |
| Team | Spread | ML | Total |
| #12 McNeese | +7.5 (-110) | +275 | O 133.5 (-110) |
| #5 Clemson | -7.5 (-110) | -345 | U 133.5 (-110) |
| Team | Spread | ML | Total |
| #10 Utah State | +5.5 (-110) | +190 | O 144.5 (-110) |
| #7 UCLA | -5.5 (-110) | -230 | U 144.5(-110) |
| Team | Spread | ML | Total |
| #15 Wofford | +18.5 (-110) | +1500 | O 133.5 (-110) |
| #2 Tennessee | -18.5 (-110) | -3600 | U 133.5 (-110) |
| Team | Spread | ML | Total |
| #9 Creighton | +2.5 (-110) | +120 | O 145.5 (-110) |
| #8 Louisville | -2.5 (-110) | -142 | U 145.5 (-110) |
| Team | Spread | ML | Total |
| #13 Grand Canyon | +10.5 (-115) | +440 | O 150.5 (-108) |
| #4 Maryland | -10.5 (-105) | -600 | U 150.5 (-112) |
After it was announced that Cooper Flagg’s ankle injury would not keep him out of the NCAA Tournament, the Duke Blue Devils went back to being the outright favorites in the 2025 March Madness odds.
DRAFTKINGS SPORTSBOOKOffer
T&Cs
Sign Up Today & Receive Up to
$1,050 in Bonuses!
GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY).
Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS). Pass-thru of per wager tax may apply in IL. 1 per new customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $300 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Token expires 2/1/26. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 1/25/26 at 11:59 PM ET. Sponsored by DK.
LOCK IN PROMO
SIGNUP PROMO
SIGN UP
& GET $1,050BONUS BETS + DEPOSIT BONUS
GET PROMO
Odds updated at of 11:54 atm ET, March 17, at DraftKings. The remainder of the copy in the table below was published on March 16, immediately after the opening first-round odds were posted. Many of the lines have moved in the interim. Get all of SBD’s March Madness bracket tips before making your first-round picks.
#12 Colorado State Favored Over #5 Memphis
The only double-digit seed that is a betting favorite over its first-round opponent is the #12 Colorado State Rams, who went 25-9 (16-4 Mountain West), laying 3.5 points against the #5 Memphis Tigers, who are 29-5 (16-2 AAC). This line actually opened at CSU -2.5 but was immediately bet up by a full point to 3.5.
This spread is entirely motivated by analytics sites like KenPom, Torvik, and Haslametrics, which all rate the Rams higher than the Tigers. At the latter two, Colorado State is in the high 30s, while Memphis is in the mid 60s.
Biggest First-Round Spreads: SIU Edwardsville vs Houston
The biggest spread of the first round is a whopper. The South #1 Houston Cougars are laying 27.5 points against the #16 SIUE Cougars, despite the total being the lowest on the board (more on this later) at 127.5.
The second-biggest spread is the West #1 Florida Gators laying 26.5 points against the #16 Norfolk State Spartans. Florida has been arguably the best team in the nation the last month of the season, and they cruised to the SEC Tournament title, winning all three games by at least nine points.
Highest First-Round Total: Akron vs Arizona
The highest total on the board is 167.5 in #13 Akron Zips vs #4 Arizona Wildcats. These are two up-temp teams. Arizona plays at the 54th-fastest tempo in DI and Akron is even faster at 16th. Both teams are also considerably better on offense than they are on defense. The Wildcats have the #12 offense per KenPom’s efficiency ratings and #33 defense. Akron sits at #68 on offense and a concerning #183 on defense.
Arizona went 19-15 over/under this season, while Arkon was one of the better over bets in the nation all year, going 19-12-1 O/U, a profitable 61.3% cover rate for over bettors.
Lowest First-Round Total: SIU Edwardsville vs Houston
At the other end of the spectrum from Akron/Zona is what’s sure to be a slow-paced game between #16 SIU Edwardsville Cougars and #1 Houston Cougars, which has a total of just 127.5. Houston has the top-rated defense in the country and plays at the fifth-slowest pace of all 364 DI teams. SIUE has an anemic offense (rated #255) and plays at a slower-than average pace (261st).
KenPom projects a lopsided 75-51 Houston victory.
Houston is 14-19-1 O/U on the season. SIUE is 15-16.
BETMGM SPORTSBOOKUSE CODE SBD1500 TO GET UP TO $1,500 PAID BACK
CLAIM OFFER
BET365 SPORTSBOOKBET $10 & GET $200 IN BONUS BETS WITH CODE DIME365
CLAIM OFFER
THESCORE BET SPORTSBOOKUSE CODE DIME TO GET 100% BET RESET UP TO $1,000
CLAIM OFFER
DRAFTKINGS SPORTSBOOKBET $5 & GET $300 IN BONUS BETS IF YOUR BET WINS!
CLAIM OFFER
FANDUEL SPORTSBOOKBET $5 & GET $250 IN BONUS BETS IF YOUR BET WINS!
CLAIM OFFER
CAESARS SPORTSBOOKUSE CODE SBDDYW & DOUBLE YOUR WINNINGS ON YOUR FIRST 10 WAGERS!
CLAIM OFFER
FANATICS SPORTSBOOKGET 100% BET MATCH UP TO $100 FOR 10 DAYS
CLAIM OFFER
DRAFTKINGS T&Cs: GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in NH/OR/ONT/PR. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings Sportsbook customer. Must register new account to receive reward Token. Must select Token BEFORE placing min. $5 bet to receive $300 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Bet must settle by and Token expires 5/3/26 at 11:59 PM ET. Bonus Bets expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 4/26/26 at 11:59 PM ET.
BET365 SPORTSBOOK T&Cs: GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/MO/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ only (18+ KY). Must be present in AZ/CO/IA/IL/IN/KS/KY/LA (select parishes)/MD/MO/NC/NJ/OH/PA/TN/VA. Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. New customers only. T&CS, time limits and exclusions apply.
BETMGM T&Cs: Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US), Call 877-8-HOPENY or text HOPENY (467369) (NY), Call 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.